Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssiut University
About this trial
This randomized controlled trial aims to compare the efficacy and safety of high-velocity nasal insufflation (HVNI) versus standard noninvasive ventilation (NIV) in adult patients experiencing acute exacerbations of community-acquired pneumonia (CAP) accompanied by hypoxemic respiratory failure. The primary focus is on assessing treatment failure within 48 hours, defined as the need for intubation or death. Secondary outcomes include evaluations of gas exchange parameters, patient comfort levels, duration of ICU stay, and 28-day mortality rates.
Eligibility criteria
Qualifiers
Age ≥ 18 years
Clinical and radiographic diagnosis of CAP
Respiratory failure using partial pressure of oxygen (PaO₂) and fraction of inspired oxygen (FiO₂) is defined by a partial pressure of oxygen/fraction of inspired oxygen ratio (PaO₂/FiO₂) ≤ 300 mmHg or a respiratory rate (RR) ≥ 25/min
Informed consent obtained
Disqualifiers
Hemodynamic instability requiring vasopressors
Altered mental status Glasgow Coma Scale (GCS < 13)
Contraindication to NIV or HVNI (facial trauma, recent upper airway surgery)
Do-Not-Intubate (DNI) order
Trial design
Treatments tested in this trial
- Non-Invasive ventilation (NIV)
- High Velocity Nasal Insufflation
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov