Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMassachusetts General Hospital

About this trial

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

Eligibility criteria

Qualifiers

Age 18-80 years

Listed for liver transplantation at MGH

Calculated MELD-Na score <= 25

Able to consent

Disqualifiers

Status 1a

Cardiac or pulmonary disease

Prior liver transplant

Requiring pressors at the time of liver offer

Trial design

Treatments tested in this trial

  • Normothermic machine perfusion (NMP) of steatotic liver

Treatment groups

200 Participants
are divided into 1 treatment group

Sponsors and collaborators