Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
ConditionLiver Transplant
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMassachusetts General Hospital
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
Age 18-80 years
Listed for liver transplantation at MGH
Calculated MELD-Na score <= 25
Able to consent
Status 1a
Cardiac or pulmonary disease
Prior liver transplant
Requiring pressors at the time of liver offer