Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPeking University First Hospital
About this trial
The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).
Eligibility criteria
Qualifiers
Age ≥18 years;
Scheduled to undergo unilateral radical nephrectomy.
Disqualifiers
Solitary kidney;
Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR <30 mL/min/1.73m²);
Tumor invasion of the vena cava requiring thrombectomy;
Other conditions deemed by the investigator as unsuitable for participation in this study.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
60 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov