Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
ConditionE Cigarette Use
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16+
SponsorWestern University, Canada
About this trial
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Eligibility criteria
Qualifiers
Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
Male and female participant age ≥16 years.
Participant has recently started vaping, >1 and <5 years weekly use.
70 participants will be c-cigarette never users.
Disqualifiers
Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.
Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.
Participant unable to perform spirometry or plethysmography maneuvers.
Trial design
Treatments tested in this trial
- Hyperpolarized Xenon-129 MRI of the lungs
- Computed Tomography (CT)
- Pulmonary Function Tests (PFT)
- Cardiopulmonary exercise testing (CPET)
- Sputum analysis
- Blood analysis
- Questionnaires
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
Western University, Canada
Lead sponsor
London Health Sciences Centre
Collaborator
Source ClinicalTrials.gov