NR vs. Vitamin E in Enhancing Fertility
ConditionInfertility Female
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age35-42
SponsorThe First Affiliated Hospital of Zhengzhou University
About this trial
This randomized controlled trial enrolled women of advanced maternal age (≥35 years) undergoing ART, who were allocated to an intervention group (oral nicotinamide riboside, NR) or a control group (oral vitamin E, VitE) for a 2-month pre-ART intervention. The study systematically evaluated NR's regulatory effects on ovarian function and ART outcomes by measuring NAD+ levels in ovarian granulosa cells (GCs) and peripheral blood mononuclear cells (PBMCs), anti-Müllerian hormone (AMH) concentrations.
Eligibility criteria
Qualifiers
Infertile women aged between 35 and 42 years;
0.1 ng/mL <= AMH <= 1.1 ng/ml;
Pregnancy aids who plan to perform in vitro fertilization and embryo transfer (antagonist program);
Bilateral ovaries are present;
Disqualifiers
Adenomyosis and uterine fibroids compression of uterine uterine line;
Untreated bilateral hydrosalpinx;
Uncured endometrial disease;
Any pregnancy occurred within 3 months before screening;
Trial design
Treatments tested in this trial
- NR
- Vit E
Treatment groups
60 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov