O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
About this trial
The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.
The main questions it aims to answer are:
1. Do common maneuvers for hemodynamic optimization (fluid bolus and/or vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator? 2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas?
Participants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.
Eligibility criteria
Qualifiers
Heart rate > 120 bpm
Urinary output < 0.5 ml/kg/h for at least two hours
Lactate > 2 mmol/L
Disqualifiers
Urgent need for surgery
Urgent need for veno-arterial ECMO or severe hemodynamic instability
Consistent risk of imminent death
Severe ARDS or severe respiratory failure (p/F < 100 mmHg) and/or FiO2>0.8
Trial design
Treatments tested in this trial
- Noradrenalin
- Fluid bolus
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov