Ocular Blood Flow Imaging for Glaucoma Assessment
ConditionGlaucoma
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-88
SponsorUniversity of Maryland, Baltimore
About this trial
The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management.
The main question it aims to answer are:
* Can the investigators use blood flow to discriminate between eyes with early-stage glaucoma and variable-matched controls? * Can the investigators validate that the XyCAM FC simultaneously captures both stereo fundus photography and ocular blood flow monitoring?
Participants will be
* measured for their blood pressure, heart rate, height, and weight * dilated with tropicamide * imaged using the XyCAM RI, fundus photography, optical coherence tomography, and standard automated perimetry * imaged using the XyCAM RI while inhaling 100% oxygen through a mask
Eligibility criteria
Qualifiers
Age 18 and older with binocular vision
Able to provide informed consent
Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria
Disqualifiers
The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)
The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy
The subject has prior ocular disease other than glaucoma
The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye
Trial design
Treatments tested in this trial
- XyCAM with oxygen
Treatment groups
150 Participants
are divided into 3 treatment groupsSponsors and collaborators
University of Maryland, Baltimore
Lead sponsor
National Eye Institute (NEI)
Collaborator
Vasoptic Medical, Inc
Collaborator
Source ClinicalTrials.gov