Olfactory Biopsies
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorDuke University
About this trial
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell.
The purpose of this study is to collect tissue from the nasal cavity.
Eligibility criteria
Qualifiers
Between the ages of 18 and 80
Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)
Disqualifiers
Advanced Alzheimer's/dementia
Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
Active Rhinosinusitis symptoms
Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)
Trial design
Treatments tested in this trial
- olfactory testing
- Odor stimulation
- Olfactory biopsy
Treatment groups
125 Participants
are divided into 2 treatment groupsSponsors and collaborators
Duke University
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator
Source ClinicalTrials.gov