A prospective, multicenter, single-arm non-inferiority trial to demonstrate that breast cancer patients who are predicted to have a pathologic complete response on MRI and vacuum-assisted biopsy after neoadjuvant systemic therapy, and are omitted breast surgery have a non-inferior 5-year disease-free survival compared to those who had received breast surgery.
Sex: female
Age: 20 years and older
Patients with no clinical/radiologic distant metastasis
Tumor type: Invasive ductal carcinoma
Multifocal lesion (≥2)
Extent of residual microcalcification after neoadjuvant chemotherapy > 2cm
Bilateral breast cancer or inflammatory breast cancer
Contraindication to radiotherapy
Seoul National University Hospital
Lead sponsor
Ministry of Health & Welfare, Korea
Collaborator