The goal of this observational prospective multicentric study, 12 months duration is to investigate whether the history of Chronic Migraine and, more precisely, its duration for over or less than 10 years, can predict OBT-A treatment effectiveness.
Since CM patients may have a complex psychopathological profile and psychiatric symptoms represent a bad prognostic factor influencing treatment effectiveness, the present study will also aim at evaluating if the psychopathological profile of the enrolled patients may influence the outcome.
Age between 18 and 70 years-old
Chronic Migraine defined according to 1.3 ICHD-3
Informed consent
secondary headache
Onabotulinumtoxin-A in the previous 3 months
pregnancy or breastfeeding
detoxification protocol for Medication Overuse Headache in the last 6 months