Onco-Genomas Brasil: Mapping Breast and Prostate Cancer in the Brazilian Public Health System
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHospital Moinhos de Vento
About this trial
This project aims to perform complete sequencing of the somatic (tumor) and germline exomes during clinical investigation of cancer patients treated through the Brazilian Unified Health System to generate genomic and phenotypic data for the Brazilian Ministry of Health's National Precision Genomics and Health Program, called Genomas Brasil, as well as to collect data on the population's ancestry.
Eligibility criteria
Qualifiers
Women aged ≥ 18 years;
Brazilian nationality;
After review at the Hospital Moinhos de Vento, confirmed histological diagnosis of breast carcinoma with overexpression of HER2 (classified by immunohistochemistry as 3+ or 2+ with positive in-situ hybridization) or triple-negative (estrogen and progesterone receptors <1% and no overexpression of HER2);
Clinical stage II or III for HER2-positive and I, II and III for triple-negative patients - American Joint Committee on Cancer (AJCC) 8th edition;
Disqualifiers
No available paraffin-embedded tumor tissue for genomic analysis;
Inability to collect blood for genomic evaluation.
Trial design
Treatments tested in this trial
- whole exome and whole genome sequencing analysis
Treatment groups
882 Participants
are divided into 2 treatment groupsSponsors and collaborators
Hospital Moinhos de Vento
Lead sponsor
Ministry of Health, Brazil
Collaborator
Source ClinicalTrials.gov