Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorJohn Kirkwood

About this trial

This translational study will examine the immune effector responses of patients who received a two-drug combination for first line therapy by examining tumor and peripheral blood of participants with unresectable locally advanced or metastatic melanoma.

Eligibility criteria

Qualifiers

Study participants who meet inclusion criteria for the HCC 24-056 study will be eligible for this study.

3 additional tumor biopsies

3 additional blood draws

Participants must have biopsiable non-target disease amenable to at least 3 biopsies.

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Fianlimab + Cemiplimab
  • Relatlimab + Nivolumab

Treatment groups

20 Participants
are divided into 2 treatment groups

Sponsors and collaborators

John Kirkwood

Lead sponsor

University of Pittsburgh

Sponsor institution

Regeneron Pharmaceuticals

Collaborator