Optimal Pacing Rate for Cardiac Resynchronization Therapy
ConditionAtrial Fibrillation, Persistent
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-90
SponsorMedstar Health Research Institute
About this trial
This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test. The investigators will randomly assign half of the participants to a starting rate of 60 bpm and then switch them to a rate of 80 bpm for 3 months, and vice versa.
Eligibility criteria
Qualifiers
Age 18 years or older
History of persistent or permanent atrial fibrillation
Implantation of CRT or conduction system pacing in prior 3 months to 5 years of study start
History of intrinsic AVN block or have undergone AVN ablation in prior 3 months to 5 years of study start
Disqualifiers
LVEF <50%
Wide QRS (greater than 150ms)
Isolated RV pacing
Severe valvular disease
Trial design
Treatments tested in this trial
- Pacing rate of 80 bpm
- Pacing rate of 60 bpm
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Medstar Health Research Institute
Lead sponsor
Medtronic
Collaborator
Source ClinicalTrials.gov