Optimization of NIBS for Treatment of Addiction
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorCase Western Reserve University
About this trial
The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.
Eligibility criteria
Qualifiers
Provide informed consent
Age 18-85 years
Diagnosis of opioid use disorder (DSM-5) with ongoing non-prescription opioid use confirmed by self-report and urine toxicology
Report current opioid craving
Disqualifiers
Are pregnant
Have frequent illicit stimulant use or acute stimulant intoxication
Are using substances or medications that may interfere with study assessments (e.g., stimulant medications, buprenorphine-based therapies, naltrexone)
Have significant neurological conditions (e.g., stroke, epilepsy, brain tumor), abnormal EEG findings, history of brain surgery, significant head injury, or unexplained syncope
Trial design
Treatments tested in this trial
- Active Comparator: Active tDCS + Active TUS
- Sham Comparator: Sham tDCS + Sham TUS
Treatment groups
126 Participants
are divided into 2 treatment groupsSponsors and collaborators
Case Western Reserve University
Lead sponsor
Highland Instruments, Inc.
Collaborator
Source ClinicalTrials.gov