Optimization of Respiratory Effort With Titrated Sedation in AHRF
ConditionAHRF
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
About this trial
Prospective, observational, monocentric study to assess the physiological effects of dexmedetomidine and remifentanil in spontaneously breathing patients with acute hypoxemic respiratory failure receiving high-flow nasal oxygen.
Eligibility criteria
Qualifiers
Age ≥18 years
PaO2/FiO2 ratio ≤ 200;
PaCO2 < 45 mmHg;
At least one symptom prompting the use of sedative-analgesic drugs according to the prescription of the attending physician: dyspnea and/or discomfort equal of greater than 4/10 (Visual Analog Scale - VAS), respiratory rate equal or greater than 25 breaths per minute, PaCO2<35 mmHg, pain (Numeric Rating Scale ≥ 4 or Behavioral Pain Scale - Non-Intubated ≥ 4);
Disqualifiers
Pregnancy;
Exacerbation of asthma or chronic obstructive pulmonary disease;
Chronic lung disease, requiring oxygen therapy at home;
Cardiogenic pulmonary oedema;
Trial design
Treatments tested in this trial
- Not listed
Trial groups
40 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov