Optimized Strategies for Malperfusion Syndrome
ConditionAortic Dissection
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorXiamen Cardiovascular Hospital, Xiamen University
About this trial
An investigator-initiated, randomized, multicenter, two-arm, open-label study of consecutive patients presenting with acute type A aortic dissection (ATAAD) and malperfusion syndrome (MPS).
Objectives: The present study aimed to investigate the difference in all-cause mortality after optimized treatment strategies (OTS) versus traditional treatment strategies (TTS) for ATAAD patients with MPS.
Background: The mortality of ATAAD with MPS is high. However, the management strategies of MPS patients still not to be confirmed. Compare with TTS, OTS as a strategy for ATAAD patients with MPS might have be beneficial results.
Eligibility criteria
Qualifiers
Provision of informed consent prior to any study specific procedures;
Acute type A aortic dissection is confirmed by computed tomography angiography;
The symptoms onset within 2 weeks;
Radiographic findings reveal occlusion of the corresponding arteries (including either coronary artery, either carotid artery, celiac trunk, superior mesenteric artery or either iliac artery);
Disqualifiers
Age <18 yr and >80 yr;
Unstable condition with cardiac tamponade or aortic rupture on admission;
Multiple types of malperfusion syndrome on admission;
Bloody stools or melena on admission;
Trial design
Treatments tested in this trial
- Optimized treatment strategies
- Traditional treatment strategies
Treatment groups
236 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov