About this trial
During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss. However, fluid restriction may lead to inadequate perfusion of vital organs and even contribute to postoperative organ dysfunction, such as acute kidney injury (AKI). Therefore, this study aims to compare the effects of restrictive versus liberal fluid therapy on major complications following hepatectomy.
Eligibility criteria
Qualifiers
scheduled for elective hepatectomy under general anesthesia
age ≥18 yrs old
Disqualifiers
American society of anesthesiologists status over 3
existed kidney disease or renal dysfunction
severe cardiac or respiratory dysfunction
neurological or psychiatric disease
Trial design
Treatments tested in this trial
- restrictive fluid infusion
- preload
- nitro
Treatment groups
Locations
Sponsors and collaborators
Zhihong LU
Lead sponsor
Air Force Military Medical University, China
Sponsor institution