Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorZhihong LU

About this trial

During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss. However, fluid restriction may lead to inadequate perfusion of vital organs and even contribute to postoperative organ dysfunction, such as acute kidney injury (AKI). Therefore, this study aims to compare the effects of restrictive versus liberal fluid therapy on major complications following hepatectomy.

Eligibility criteria

Qualifiers

scheduled for elective hepatectomy under general anesthesia

age ≥18 yrs old

Disqualifiers

American society of anesthesiologists status over 3

existed kidney disease or renal dysfunction

severe cardiac or respiratory dysfunction

neurological or psychiatric disease

Trial design

Treatments tested in this trial

  • restrictive fluid infusion
  • preload
  • nitro

Treatment groups

90 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Zhihong LU

Lead sponsor

Air Force Military Medical University, China

Sponsor institution