Optimizing Operational Parameters for Diagnostic Vitrectomy
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorIRCCS San Raffaele
About this trial
Single-center ex-vivo study using blood samples from healthy donors processed through a 25-gauge vitrectomy system. The study compares four combinations of operational parameters (vacuum pressure and cut rate) to evaluate their impact on cellular recovery and morphological preservation. Pre- and post-procedure complete blood counts and cytology smears will be analyzed to identify the settings that minimize cell loss and mechanical damage, with the ultimate goal of optimizing diagnostic yield in vitreoretinal lymphoma (VRL) vitrectomy.
Eligibility criteria
Qualifiers
Provision of written informed consent authorizing the anonymized research use of residual blood samples.
Age 18-65 years at the time of donation.
Eligibility for routine whole blood donation, according to the institutional and national standards of the Blood Transfusion Center.
Good general health, as per standard donor screening procedures.
Disqualifiers
None
Trial design
Treatments tested in this trial
- Simulated vitrectomy
Treatment groups
100 Participants
are divided into 4 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov