The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.
Aged 18 to 75 years (inclusive)
Genetically confirmed Huntington's disease with HTT CAG repeat length of 40 or greater
Unified Huntington's Disease Rating Scale Total Maximal Chorea score of 8 or higher on a scale of 0 to 28, with higher scores indicating more severe chorea
Huntington's Disease Integrated Staging System stage 2 or 3
History of self-injury, aggressive behavior, or unstable psychiatric disorders
History of head injury or neurosurgical procedure
Presence of intracranial implants, metallic foreign bodies, cochlear implants, or cardiac pacemakers
Severe systemic disease, pregnancy, or breastfeeding