Optimizing Stimulation Parameters for Electroconvulsive Therapy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorUniversity of Pennsylvania
About this trial
The goal of this clinical trial is to improve how electroconvulsive therapy (ECT) stimulation settings are chosen. Researchers will use real-time brain monitoring to measure both seizures and a recently identified brain event called cortical spreading depolarization (CSD).
The main questions it aims to answer are:
What is the best way to increase ECT stimulation settings? How do different pulse settings affect the brain's response? Can certain settings produce CSD without causing a seizure?
Participants already receiving ECT as part of their care will take part. They will be assigned to one of two groups:
Index ECT group: Participants starting ECT will receive different standard titration approaches.
Maintenance ECT group: Participants receiving ongoing ECT will undergo a brief, low-dose stimulation test before treatment.
All participants will be monitored using brain physiology (EEG and blood flow) and symptom scales during treatment.
Eligibility criteria
Qualifiers
Any patients being treated with electroconvulsive therapy at Pennsylvania Hospital who are willing and able to participate are eligible to be subjects in this study.
Disqualifiers
They are unwilling or unable to consent first to the SWEET COMBO protocol for optical monitoring during ECT
Clinically significant psychiatric comorbidity as determined by clinical interview and in the opinion of the Investigator and clinical team would alter the risk/benefit of the study
History of poor response to ECT treatment in the opinion of the Investigator and clinical team that would alter the risk/benefit of the study
subject's ability to participate safely in the study
Trial design
Treatments tested in this trial
- Electroconvulsive Therapy
Treatment groups
64 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov