Oral Health and Wilson's Disease: SOMAWI
ConditionWilson Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondation Ophtalmologique Adolphe de Rothschild
About this trial
Patients with Wilson disease have poorer dental and periodontal health and a have lower oral quality of life than control patients. Patients with a neurological form would also more frequently present limitations in the function of the masticatory apparatus. Systemic treatments for Wilson disease are associated with lesions of the oral mucosa. Analysis of copper level in saliva could testify to the effectiveness of copper depletion in treated patients The main objective is to compare the state of dental health between: patients with Wilson disease in the hepatic form and patients with the neurological form, and a population of controls.
Eligibility criteria
Qualifiers
Express consent to participate in the study
Member of or beneficiary of a social security scheme
For cases: Affected by Wilson's disease
For controls: Benefiting from a first routine dental consultation with dental panoramic imaging, outside of an emergency context or treatment follow-up/maintenance
Disqualifiers
Patient benefiting from a legal protection measure
Pregnant or breastfeeding women
Severe psychiatric disorders with behavioral disorders
hepatic or neurological decompensation
Trial design
Treatments tested in this trial
- Saliva samples
- Questionnaire OHIP-14
- Thorough dental examination
Treatment groups
150 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov