Overlapping Pain Trajectory Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age10-19
SponsorChildren's Hospital Medical Center, Cincinnati

About this trial

The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are:

1. If spatial and temporal filtering of nociceptive information is disrupted in youth with COPCs compared with youth with localized pain conditions and healthy controls. 2. If disrupted nociceptive processing at baseline is associated with the transition from a single localized pain condition to COPCs in youth.

Participation includes:

* quantitative sensory testing * blood draw * sleep assessment * questionnaires

Eligibility criteria

Qualifiers

General Criteria

Access to the internet either by laptop, tablet, or phone (for REDCap Surveys)

English-speaking

Parent or guardian willing to comply with protocol, complete study assessments, and provide written informed consent

Disqualifiers

General Criteria

Skin conditions (e.g., eczema) or past skin damage on the arms and legs in or near sites of sensory testing

Any comorbid rheumatic disease (e.g., arthritis, lupus), neurological (e.g., epilepsy, traumatic brain injury) or medical condition (e.g., cancer, diabetes)

Control Specific Criteria

Trial design

Treatments tested in this trial

  • Conditioned Pain Modulation
  • Offset Analgesia
  • Spatial Summation
  • Temporal Summation

Treatment groups

420 Participants
are divided into 3 treatment groups