Oxalate and Citrate
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity of Chicago
About this trial
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
Eligibility criteria
Qualifiers
Age 18-70
History of at least one calcium-based kidney stone
Age 18-70
No history of kidney stone
Disqualifiers
History of primarily uric acid, cysteine, or struvite stones.
History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.
Trial design
Treatments tested in this trial
- Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov