Oxygen Extraction-guided Transfusion
ConditionBlood Transfusion
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversità degli Studi di Ferrara
About this trial
In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level \< 7.0 g/dL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients \[11\]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.
Eligibility criteria
Qualifiers
Hb levels ≤ 9.0 g/dL (as confirmed through a blood test and/or through blood gas analysis)
Presence of an arterial line and a central venous line (either jugular or subclavian), with confirmed correct position of the catheter tip at the atrio-caval junction (allowing correct estimation of central venous saturation, ScvO2).
Disqualifiers
Age < 18 years;
Pregnancy
Clinical evidence of acute bleeding
Diagnosis of haematological malignancy
Trial design
Treatments tested in this trial
- Individualized red blood cell transfusion strategy
- European guidelines red blood cell transfusion strategy
Treatment groups
324 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov