About this trial
The present study is proposed to compare a rapid fractionation schedule of 1 week compared to a protracted schedule of 6-8 weeks for palliation for locally advanced cervical cancer.
Eligibility criteria
Qualifiers
Very large volume hard fixed disease infiltrating pelvic wall muscles and ligaments on clinical examination also classified clinically as "frozen pelvis" wherein curative intent treatment is not envisaged or feasible.
Fistulous communication between tumour growth and rectum and bladder >2x2 cm in size (as judged by cystoscopy for bladder infiltration or clinical or proctosigmoidoscopy examination for rectal/sigmoid infiltration) wherein radical intent treatment is not intended or feasible and patient is not a candidate for pelvic exenteration.
Deranged renal parameters as measured by Serum Creatinine >3 mg/dl wherein diversion nephrostomy is not planned by the multidisciplinary team due to anticipated poor clinical outcomes.Furthermore concurrence for palliative intent radiotherapy should be corroborated by 2 staff radiation oncologists.
Moderate to Severe Pain on Numerical Rating Score (Score 4 or higher).
Disqualifiers
Patients with distant metastasis needing upfront systemic therapy.
Presence of retroviral disease
Non-compliant for follow up.
Expected survival <3 months.
Trial design
Treatments tested in this trial
- Short course palliative radiation.
- Long course palliative treatment.
Treatment groups
Sponsors and collaborators
Tata Memorial Hospital
Lead sponsor
Tata Memorial Centre
Collaborator