Palliative Radiation for Advanced Cervical Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-75
SponsorTata Memorial Hospital

About this trial

The present study is proposed to compare a rapid fractionation schedule of 1 week compared to a protracted schedule of 6-8 weeks for palliation for locally advanced cervical cancer.

Eligibility criteria

Qualifiers

Very large volume hard fixed disease infiltrating pelvic wall muscles and ligaments on clinical examination also classified clinically as "frozen pelvis" wherein curative intent treatment is not envisaged or feasible.

Fistulous communication between tumour growth and rectum and bladder >2x2 cm in size (as judged by cystoscopy for bladder infiltration or clinical or proctosigmoidoscopy examination for rectal/sigmoid infiltration) wherein radical intent treatment is not intended or feasible and patient is not a candidate for pelvic exenteration.

Deranged renal parameters as measured by Serum Creatinine >3 mg/dl wherein diversion nephrostomy is not planned by the multidisciplinary team due to anticipated poor clinical outcomes.Furthermore concurrence for palliative intent radiotherapy should be corroborated by 2 staff radiation oncologists.

Moderate to Severe Pain on Numerical Rating Score (Score 4 or higher).

Disqualifiers

Patients with distant metastasis needing upfront systemic therapy.

Presence of retroviral disease

Non-compliant for follow up.

Expected survival <3 months.

Trial design

Treatments tested in this trial

  • Short course palliative radiation.
  • Long course palliative treatment.

Treatment groups

230 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Tata Memorial Hospital

Lead sponsor

Tata Memorial Centre

Collaborator