Pancreatic Cancer Screening for At-risk Individuals

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorBeth Israel Deaconess Medical Center

About this trial

The investigators' goal is to conduct a prospective multicenter study to evaluate the yield and outcomes of screening of pancreas cancer in individuals who are at-risk for pancreatic cancer. We plan to use International Cancer of the Pancreas Screening (CAPS3) Consortium recommendations to standardize study population, screening methodology, and study outcomes.

Eligibility criteria

Qualifiers

Inclusion criteria 1-3 are indications for pancreatic cancer screening as defined by the CAPS3 guidelines or updated national pancreatic cancer screening guidelines. Patients who do not meet these guidelines but are undergoing pancreatic cancer screening at the discretion of their treating physician at participating study centers will also be included in the study. Based upon the indication for screening, patients will be categorized as either meeting CAPS3 screening criteria, or not meeting CAPS3 screening criteria.

Familial Pancreatic cancer kindred. This is defined as family history of pancreas cancer that meet the criteria listed below.

If at least two affected relatives who are First degree relatives (FDR) to each other, of whom at least one is an FDR to the individual considered for surveillance

If at least three affected relatives on the same side of the family, of whom at least one is an FDR to the individual considered for surveillance

Disqualifiers

Patients presenting with symptoms suggestive of pancreatic cancer who are undergoing diagnostic EUS or MRCP e.g. acute recurrent pancreatitis, abnormal imaging

Trial design

Treatments tested in this trial

  • Screening for pancreatic cancer

Treatment groups

1,395 Participants
are divided into 1 treatment group

Sponsors and collaborators

Beth Israel Deaconess Medical Center

Lead sponsor

Washington University School of Medicine

Collaborator

Zucker School of Medicine at Hofstra/Northwell

Collaborator

Rush University Medical Center

Collaborator

Wake Forest University

Collaborator

University of Arkansas

Collaborator