This randomized, open-label, single-centre controlled study evaluates the efficacy and safety of combined paracetamol and ibuprofen therapy with versus without famotidine in the treatment of calcific tendinitis of the shoulder. Outcomes include pain reduction, functional improvement, radiological changes, and need for additional interventions over a 12-month follow-up period.
Age ≥18 years
Clinical history of shoulder pain consistent with calcific tendinitis
Presence of calcifications confirmed by shoulder X-ray
Ability and willingness to comply with study procedures and follow-up
Known allergy or hypersensitivity to paracetamol, ibuprofen, or famotidine
Active gastrointestinal disease contraindicating NSAID use
Chronic dual antiplatelet therapy
Current use of proton pump inhibitors other than pantoprazole (unless temporarily replaced)