Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network with a wide frequency range. In the present project, we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD (subthalamic deep brain stimulation (STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and hyperkinetic), using a simple motor task.
Male or Female
18 to 75 years-old
With idiopathic Parkinson's disease
Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
Be incapable of giving consent personally.
Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
Being pregnant or breastfeeding
Present a serious and/or decompensated somatic or psychiatric illness.
University Hospital, Bordeaux
Lead sponsor
Université de Bordeaux, IMN, UMR CNRS 5293
Collaborator