Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-90
SponsorCentraCare

About this trial

In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.

Eligibility criteria

Qualifiers

Age between 30 - 90 years

Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension

Diagnosis of ARDS with PF ratio < 150 , PEEP > 8

Patients who are under paralysis or deeply sedated, on a mechanical ventilator

Disqualifiers

Patients with arrhythmias including atrial fibrillation

Patients with chest tube, intra-abdominal hypertension or with its risk factors

Patients with structural heart disease including pulmonary hypertension (RVSP > 45) and heart failure

Patients on extracorporeal support such as ECMO, CRRT or MCS.

Trial design

Treatments tested in this trial

  • Passive leg raise, SVI via bioreactance, Echo based VTI

Treatment groups

64 Participants
are divided into 2 treatment groups

Sponsors and collaborators