About this trial
In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.
Eligibility criteria
Qualifiers
Age between 30 - 90 years
Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension
Diagnosis of ARDS with PF ratio < 150 , PEEP > 8
Patients who are under paralysis or deeply sedated, on a mechanical ventilator
Disqualifiers
Patients with arrhythmias including atrial fibrillation
Patients with chest tube, intra-abdominal hypertension or with its risk factors
Patients with structural heart disease including pulmonary hypertension (RVSP > 45) and heart failure
Patients on extracorporeal support such as ECMO, CRRT or MCS.
Trial design
Treatments tested in this trial
- Passive leg raise, SVI via bioreactance, Echo based VTI