The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions.
The fundamental question it aims to answer is:
What are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis?
In this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.
Being between the ages of 18 and 65
Being diagnosed with psoriasis by a dermatologist
Having at least 20 teeth
Not having received periodontal treatment in the last 6 months
<20 teeth
Any significant oral infection (i.e., herpes or candidiasis)
Oral injuries or bleeding unrelated to periodontitis
Periodontal therapy and antibiotic therapy within the past 3 months