Health TrialsbyHealthPanel

Pathogenic Study of Adult Immune Enteropathies

ConditionsCeliac DiseaseAutoimmune EnteropathyInflammatory Bowel Diseases
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorInstitut National de la Santé Et de la Recherche Médicale, France

About this trial

The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18 years or over

affiliated to social insurance

signed informed consent

Disqualifiers

pregnancy

under guardianship

not able to sign informed consent

Trial population

Patients planned to have blood specimens and possible upper and/or lower digestive endoscopy.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Blood sample collection; gastrointestinal biopsy

    Genetic

    Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...

Treatment groups

200 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.

Group A: Active coeliac patients1 intervention
Group B: Treated coeliac patients1 intervention
Group C: Sprue type I1 intervention
Group D: Sprue type II1 intervention
Group E: Intestinal Lymphoproliferations1 intervention
Group F: Non coeliac enteropathies1 intervention
Group G: Patients without neoplastic or inflammatory intestinal disease1 intervention

Trial outcomes

Primary outcomes

1

Intestinal Lymphocytes count

Lymphocytes isolation

Time frame
Baseline
2

DNA sequencing

Targeted Next Generation sequencing

Time frame
Baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Institut National de la Santé Et de la Recherche Médicale, France

Lead sponsor

Imagine Institute

Collaborator

Source ClinicalTrials.gov
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