Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

the investigators have recently shown that patients with drug-resistant temporal lobe epilepsy who have undergone brain surgery targeting the medial temporal lobe structures were more likely to develop tinnitus postoperatively. This discovery of a vulnerability to tinnitus associated with medial temporal lobe surgery to eliminate drug-refractory epileptic seizures provides a new clinical model of tinnitus, targeting temporal lobe regions as generators or mediators of this hearing disorder. The objective of this project is to study the impact of tinnitus on the cognitive, emotional, psychoacoustic and cerebral functioning associated with this hearing disorder, and to clarify the pathophysiology of tinnitus by comparing different groups of individuals with tinnitus (surgical epileptic patients or non-surgical ORL patients) to matched tinnitus-free groups (surgical tinnitus-free cases and healthy controls volunteer).

Eligibility criteria

Qualifiers

Age ≥ 18 years old

Good written and oral comprehension of the French language

Person affiliated to a Social Security scheme

Informed consent signed by the participant

Disqualifiers

Presence of severe or profound deafness, uni or bilateral.

Under legal protection (guardianship, curators, etc.)

MRI contraindicated or claustrophobic

Pregnant or breastfeeding woman.

Trial design

Treatments tested in this trial

  • acoustics tests, Questionaries,
  • MRI

Treatment groups

300 Participants
are divided into 2 treatment groups