HOPE Focus is an observational study that aims at promoting research against metastatic breast cancer by means of collective research led by patients (patient-centric trial). Patients with metastatic breast cancer living in Spain will voluntarily register and fulfil their journey in the study through the study's digital tool. Mainly they are prompted to answer questionnaires about their disease and expectations, and to provide a blood sample and an archival tumor biopsy. In HOPE Focus these samples will be genomically analyzed and every patient case will be presented in a multidisciplinary molecular advisory board (MAB). The MAB will issue a plain report explaining the significance of the results and will enumerate future therapeutic options that match patient history and his genomic profile, when feasible. Finally, patients will have to answer short follow-up questionnaires twice a year for 3 years.
The study data will allow us to advance implementing precision medicine to improve the management of current and specially future metastatic breast cancer patients.
Female or male patients residing in Spain.
Age ≥ 18 years.
Signed informed consent prior to any study-related procedures, except for registration.
Self-reported Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
Presence of a condition or abnormality that, in the opinion of the investigators, would compromise the safety of the patient or the quality of the data.
Inability or refusal to commit with the procedures of the study at the moment of inclusion.
More than 3 prior systemic chemotherapy or antibody-drug conjugate (ADC) regimens for metastatic disease. Note: treatments for bone metastases (eg, bisphosphonates, denosumab, etc.), targeted therapies (eg, PARP inhibitors, CDK 4/6 inhibitors, immunotherapy etc.) and hormonal therapy are not considered as prior systemic chemotherapy treatments for advanced disease.
SOLTI Breast Cancer Research Group
Lead sponsor
Roche Farma, S.A
Collaborator
Menarini Group
Collaborator
AstraZeneca
Collaborator
Pfizer
Collaborator
Eli Lilly and Company
Collaborator