About this trial
To evaluate the consistency of drug efficacy between the clinical systemic treatment and drug sensitive test based on patient-derived organoid in R/M SGC patients, using a prospective and multicenter observational study to increase the generalizability and reliability of research conclusion.
Eligibility criteria
Qualifiers
Pathologically confirmed R/M SGC patients
Tumor tissues available for organoid culture
ECOG score: 0-2 points
Life expectancy > 3 months
Disqualifiers
Metastatic tumors in the head and neck region, or non-salivary gland cancer tumors such as sarcoma, squamous cell carcinoma, nasopharyngeal carcinoma, etc.
Known allergy to the study drugs or their active ingredients or any excipients; or had a severe allergic reaction to other monoclonal antibodies
Pregnant or breastfeeding female patients; or women of childbearing age with positive pregnancy test results (serum or urine) within 7 days before enrollment, or negative results but refusing to use effective contraception during the study period and 2 months after the last administration of study medication; or male patients with partners of childbearing age, refusing to use effective contraception during the study period and 2 months after the last administration of study medication
Severe liver diseases (such as cirrhosis), kidney diseases, respiratory system diseases, hematopoietic system diseases, or endocrine system diseases, uncontrolled diseases
Trial design
Treatments tested in this trial
- No Intervention: Observational Cohort
Treatment groups
Sponsors and collaborators
Huashan Hospital
Lead sponsor
Shanghai Cancer Hospital, China
Collaborator
Eye & ENT Hospital of Fudan University
Collaborator
Dongfang Hospital Affiliated to Tongji University
Collaborator
Shandong Cancer Hospital and Institute
Collaborator
Qilu Hospital of Shandong University
Collaborator
Shandong Provincial Hospital
Collaborator
Hospital of Stomatology, Wuhan University
Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborator
Zhejiang University
Collaborator
Sir Run Run Shaw Hospital
Collaborator
Zhejiang Cancer Hospital
Collaborator
Shanghai Huangpu District Central Hospital
Collaborator
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborator
Wuhan TongJi Hospital
Collaborator
Zhongnan Hospital
Collaborator