Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
patients admitted to the pediatric intensive care unit or cardiac intensive care unit
patient age : 1,8 kg-15 years
patient receiving antibiotic treatment (piperacillin-tazobactam, meropenem, amoxicillin-clavulanate, cephazolin, vancomycin, teicoplanin, ciprofloxacin, amikacin)
intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)
no catheter in place for blood sampling
absence of parental/patient consent
known hypersensitivity to beta-lactam antibiotics and ciprofloxacin
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Treatment groupsSee each treatment group below.