About this trial
The goal of this clinical trial is to evaluate the application of intravenous contrast-enhanced ultrasound examination in children with intra-abdominal diseases that require clear diagnoses. The main questions it aims to answer are:
* Is intravenous contrast-enhanced ultrasound helpful for the diagnosis of intra-abdominal diseases in children? * What medical problems do participants have when participating in intravenous contrast-enhanced ultrasound examination? * How can ultrasound doctors conduct intravenous contrast-enhanced ultrasound examinations in a standardized manner? Researchers will performing intravenous contrast-enhanced ultrasound examinations on participants and collecting research subjects to establish a multicenter clinical data database.
Participants will:
* Perform abdominal ultrasound examination to assess the condition. * At least conduct one intravenous contrast-enhanced ultrasound examination. Based on the result of the contrast examination, decide whether to conduct another examination. * Keep a diary of their symptoms and therapeutic process in 30 days.
Eligibility criteria
Qualifiers
Age 29 days to 18 years old;
The clinical diagnosis was abdominal space-occupying lesions, blunt abdominal trauma, ascites of unknown cause, and children with suspected abdominal disease but other examinations could not identify the cause.
Disqualifiers
Allergic to sulfur hexafluoride or other components;
Heart disease with right-to-left shunt/severe pulmonary hypertension /uncontrolled systemic hypertension/respiratory failure/heart failure/severe arrhythmia;
Electrocardiogram, echocardiography or clinical manifestations of myocardial ischemia;
Patients with severe blood system diseases or infectious diseases;
Trial design
Treatments tested in this trial
- contrast-enhanced ultrasound examination
- SonoVue®
Treatment groups
Sponsors and collaborators
The Children's Hospital of Zhejiang University School of Medicine
Lead sponsor
Shenzhen Children's Hospital
Collaborator
Children's Hospital of Chongqing Medical University
Collaborator
Tianjin Children's Hospital
Collaborator
Kunming Children's Hospital
Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborator
West China Hospital
Collaborator
Yuying Children's Hospital of Wenzhou Medical University
Collaborator
Xian Children's Hospital
Collaborator