Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-18
SponsorChildren's Hospital Los Angeles
About this trial
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced. The primary and secondary aims of the study are as follows:
Identify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP/FiO2 grid recommendations.
Determine the difference in physiologic metrics between EIT optimal PEEP and the PEEP/FiO2 recommended PEEP.
Participants will undergoing EIT monitoring while being subjected to PEEP titration protocol.
Eligibility criteria
Qualifiers
Any person who is less than 18 years of age
is on invasive mechanical ventilation
is not spontaneously breathing
meets PARDS criteria
Disqualifiers
Contraindication to the use of EIT
Hemodynamic instability
Contraindications to hypercapnia
patients with uncuffed endotracheal or tracheostomy tubes
Trial design
Treatments tested in this trial
- Electrical Impedance Tomography positive end-expiratory pressure titration
Treatment groups
60 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov