PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMuehlenkreiskliniken, MKK
About this trial
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Eligibility criteria
Qualifiers
Adults >= 18 years
non-traumatic OHCA
mechanical ventilation via airway device
Disqualifiers
Patients < 18 years,
traumatic cause of OHCA,
no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)
Trial design
Treatments tested in this trial
- PEEP 5 mbar
- ZEEP 0 mbar
Treatment groups
600 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov