Perception and Integration of Sensory Information in the Early Stages of Psychosis

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorCentre Psychothérapique de Nancy

About this trial

The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:

* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk? * How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?

Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.

Participants will:

* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task. * Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials). * Provide demographic, clinical, and neuropsychological data during study visits. * For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.

Eligibility criteria

Qualifiers

Age between 18 and 30 years

Normal or corrected-to-normal visual acuity

Affiliated with or dependent on a social security health insurance plan

Provided informed consent and co-signed the study consent form with the investigator

Disqualifiers

Pregnant, postpartum, or breastfeeding women

Individuals deprived of liberty by judicial or administrative decision

Individuals in a life-threatening emergency

Adults under legal protection measures

Trial design

Treatments tested in this trial

  • behavioral tasks
  • Electroretinography
  • Comprehensive Assessment of At Risk Mental States (CAARMS)
  • Neuropsychological tests

Treatment groups

294 Participants
are divided into 1 treatment group

Sponsors and collaborators

Centre Psychothérapique de Nancy

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Collaborator