About this trial
The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:
* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk? * How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?
Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.
Participants will:
* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task. * Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials). * Provide demographic, clinical, and neuropsychological data during study visits. * For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.
Eligibility criteria
Qualifiers
Age between 18 and 30 years
Normal or corrected-to-normal visual acuity
Affiliated with or dependent on a social security health insurance plan
Provided informed consent and co-signed the study consent form with the investigator
Disqualifiers
Pregnant, postpartum, or breastfeeding women
Individuals deprived of liberty by judicial or administrative decision
Individuals in a life-threatening emergency
Adults under legal protection measures
Trial design
Treatments tested in this trial
- behavioral tasks
- Electroretinography
- Comprehensive Assessment of At Risk Mental States (CAARMS)
- Neuropsychological tests
Treatment groups
Sponsors and collaborators
Centre Psychothérapique de Nancy
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Collaborator