Perception, Sensation, Cognition and Action in Humans
ConditionNormal Physiology
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age13-65
SponsorNational Eye Institute (NEI)
About this trial
Background:
When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happens. Researchers want to explore how healthy brains process sights and sounds.
Objectives:
To explore how people understand what they see and hear when the brain processes sights and sounds.
Eligibility:
Participants aged 13-65 who have at least 20/40 vision in at least one eye and do not use a hearing aid.
Design:
Some participants will take tests online anonymously. They will do computer tasks related to colors and behavior.
In-person participants will be screened with medical history and physical exam. They will complete questionnaires and vision and hearing tests.
Participants will plan how many testing sessions they will have and when. Sessions last 2-5 hours. They may include:
* Magnetic Resonance Imaging: Magnets and radio waves to take pictures of the brain. Participants will lie on a table that slides in and out of a tube. They will do a task during the scan. * Magnetoencephalography: Records magnetic field changes from brain activity. Participants will sit or lie down. A cone will be lowered onto their head. They may do a task during the test. * Electromyography: Electrodes attached to the skin will measure the electrical activity of muscles. * Electroencephalogram: Electrodes on the scalp will record brain waves. * Electrocardiography: Electrodes on the chest will record heart electrical activity. * Tests of memory, attention, thinking, vision, and hearing. * Eye Tracking: Cameras will follow participants eye movements. They may wear a cap with infrared cameras in front of their eyes.
During the sessions, participants vital signs may be monitored.
Eligibility criteria
Qualifiers
is in good general health;
is between 18 and 65 years old;
has visual acuity of 20/40 in at least one eye (corrected with contact lenses is okay);
has no hearing impairment requiring a hearing aid.
Disqualifiers
Participant is pregnant
Participant has serious vision or hearing problems; for some sub-studies focused on mechanisms of normal color vision, subjects who are colorblind will also be excluded;
Participants without consent capacity will not be enrolled;
Participant has a debilitating neurological disorder (examples include, but are not limited to: brain tumor, epilepsy, Alzheimer's Disease, Parkinson's Disease, multiple sclerosis) or a psychiatric disorder (examples include, but are not limited to: schizophrenia, clinical anxiety, severe depression, attention deficit hyperactivity disorder (ADHD), schizophrenia). Patients with non-debilitating conditions such as prosopagnosia, prosopometamorphosia (PMO), or aphantasia will have their conditions noted but will not be excluded);
Trial design
Treatments tested in this trial
- Not listed
Trial groups
10,200 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov