Peri-implantitis Management: Surgical and Maintenance Outcomes
ConditionPeri-implantitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Pittsburgh
About this trial
The goal of this clinical trial is to learn how two standard surgical treatments for peri-implantitis affect inflammation around dental implants. Participants will be randomly assigned to receive resective surgery with implantoplasty or resective surgery with mechanical debridement only. Participants will provide blood samples before surgery, about 48 hours and 2 weeks after surgery. Participants will also provide a small gum tissue sample and fluid from around the implant at baseline and about 3 months after surgery. Participants will be followed in a maintenance program for up to 5 years.
Eligibility criteria
Qualifiers
Aged 18 or older.
In good general health, classified as ASA Physical Status I or II.
Diagnosed with peri-implantitis requiring resective surgical treatment, characterized by: Bleeding on probing (BOP) around dental implants. Probing pocket depths (PPD) greater than 6 mm. Implants in function for over 1 year with progressive bone loss exceeding 3 mm. Initial screening confirmed by panoramic radiographs, cone-beam computed tomography (CBCT), and clinical diagnosis.
Probing depth (PD) ≤ 5 mm
Disqualifiers
Patients with autoimmune or systemic inflammatory diseases (e.g., lupus, rheumatoid arthritis) that could alter immune cell profiles independent of local peri-implant inflammation.
Chronic use of systemic corticosteroids or immunosuppressants within the past 3 months.
Uncontrolled diabetes (HbA1c > 7.5%) due to its potential impact on healing and immune response.
Active infection or antibiotic use in the 30 days prior to baseline sampling.
Trial design
Treatments tested in this trial
- Resective surgery with implantoplasty
- Resective surgery with mechanical debridement
Treatment groups
44 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov