Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age38+
SponsorNational and Kapodistrian University of Athens
About this trial
The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated. To enhance the potential therapeutic effect, we will proceed to a 4-point injection technique, targeting 4 genicular nerves (superomedial, superolateral, inferomedial, recurrent peroneal genicular nerve) in a randomized controlled trial with two arms.
Eligibility criteria
Qualifiers
Patients of both sexes
Age >38 years
Body Mass Index (BMI) up to 42 kg/m2
Chronic knee pain on the Numerical Rating Scale (NRS) > 5 for at least 3 months prior to the study
Disqualifiers
Any infection of the skin of the knee joint, such as cellulitis, or periarticular or intraarticular infection during the last 3 months
Poorly controlled diabetes mellitus or connective tissue disease affecting the knee joint
History of previous total knee arthroplasty or other knee surgery.
History of periarticular or intraarticular injection of corticosteroids, local anesthetic, hyaluronic acid, platelet-rich plasma, radiofrequency, prolotherapy within the last trimester
Trial design
Treatments tested in this trial
- Dextrose 5% and Lidocaine
- Lidocaine
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov