Periodontal Disease in Patients With Lynch Syndrome
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRotundo Roberto
About this trial
The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.
Eligibility criteria
Qualifiers
Age ≥18 years;
All sexes eligible
Established diagnosis of LS performed as part of clinical practice, with a germline pathogenic/likely pathogenic variant in one of the following genes: MLH1, MSH2, MSH6, PMS2, and EpCAM
LS subjects undergoing surveillance gastrointestinal endoscopy according to clinical practice and international guidelines.
Disqualifiers
Age < 18 years;
Absence of sufficient periodontal clinical or radiographic data to establish a periodontal diagnosis;
Subjects affected by systemic, autoimmune, chronic inflammatory, neurological, or severe psychiatric disorders, or by any other clinical condition that may interfere with study participation or data interpretation
Subjects with systemic conditions known to strongly affect periodontal status (e.g. uncontrolled diabetes, autoimmune inflammatory diseases, ongoing cancer therapy) were excluded to reduce major confounding factors that could independently alter periodontal outcomes.
Trial design
Treatments tested in this trial
- periodontal charting for the diagnosis of periodontitis
Treatment groups
No treatment groups listed
Sponsors and collaborators
Rotundo Roberto
Lead sponsor
IRCCS San Raffaele
Sponsor institution
Source ClinicalTrials.gov