Periodontal Inflammation and Epigenetics in Obese Individuals
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorLouisiana State University Health Sciences Center in New Orleans
About this trial
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are:
• To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.
Eligibility criteria
Qualifiers
Adults aged ≥18 years,
No history of periodontal therapy in the last 6 months,
No use of tobacco,
No history of pregnancy lactation or contraceptive medication.
Disqualifiers
Had antimicrobial/antiviral therapy in the previous 3 months,
History of uncontrolled diabetes,
History of rheumatoid arthritis,
History of osteoporosis,
Trial design
Treatments tested in this trial
- Non-surgical periodontal therapy will be administered
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov