Perioperative Prophylactic Positive Pressure Ventilation Reduces Postoperative Pulmonary Complications.

ConditionPostoperative Pulmonary Complications (PPCs)

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-90

SponsorJun Zhang

About this trial

The incidence of postoperative pulmonary complications (PPCs) ranges from 5% to 33%. PPCs significantly prolong hospital stay, increase the economic burden, and are associated with postoperative mortality at 30 days and 1 year. The occurrence of PPCs is associated with multiple perioperative factors. A multimodal approach may provide better prevention against PPCs. We hypothesize that perioperative prophylactic positive pressure ventilation can reduce the incidence of PPCs in patients undergoing high-risk abdominal surgery.

Eligibility criteria

Qualifiers

Patients who have signed the informed consent form and are willing to comply with the study protocol;

Age ≥ 18 years and ≤ 90 years;

ASA physical status classification I to III;

Scheduled for major elective abdominal surgery;

Disqualifiers

Untreated ischemic heart disease; severe cardiovascular or cerebrovascular disease;

Severe asthma, pulmonary bullae/bullous lung disease, pneumothorax, bronchopleural fistula, etc.;

Severe underlying hepatic or renal disease;

Age < 18 years or > 90 years;

Trial design

Treatments tested in this trial

Conventional Ventilation
Perioperative positive pressure ventilation

Treatment groups

206 Participants

are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Jun Zhang

Lead sponsor

Fudan University

Sponsor institution

Source ClinicalTrials.gov