Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
ConditionAneurysm Cerebral
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMayo Clinic
About this trial
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.
Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots?
To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery.
The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.
Eligibility criteria
Qualifiers
Age > or = 18 years old
Patients willing to participate and provide an informed consent
Patients undergoing elective craniotomy for cerebral aneurysm clipping
Patients on chronic low-dose (75-100 mg) aspirin daily (aspirin group) or not on aspirin therapy for at least 7 days (control group) preoperatively.
Disqualifiers
Emergency craniotomy
Use of other antiplatelet or anticoagulant medications within 7 days prior to surgery
Known bleeding disorders (e.g. hemophilia, thrombocytopenia)
History of intracranial hemorrhage unrelated to aneurysm
Trial design
Treatments tested in this trial
- Observation
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov