The study aims to investigate how individuals with varying gut microbiota composition and AMY1 gene copy number respond to three different types of starch. A 12-week trial will therefore be conducted, where all participants will go through three different 17-day interventions in a randomized order. Each intervention will contain a different type of starch:
A) Resistant starch B) Slow digestible starch C) Rapid digestible starch
Each intervention will contain a preparation day, a meal challenge test day at clinic, a 14-day dietary intervention at home followed by a follow up visit at clinic. The interventions will be separated with a 14-day wash-out period, where participants are consuming their normal food.
Blood, saliva and fecal samples will be collected during the trial, together with data from continuous glucose monitoring and body measurements. Questionnaires on dietary intake and lifestyle, food preferences, self-reported appetite, health-related quality of life, sleep quality and daytime sleepiness will also be filled out by the participants.
Men and post-menopausal women
Age 30-75 years
BMI 27-40 kg/m2
Waist circumference > 102/88 cm for men/women
Cardiovascular events (myocardial infarction or stroke) during the previous 6 months
Diagnosis of diabetes (any type) or use of any drug who can interfere with glucose homeostasis (i.e., metformin, incretin analogues, SGLT-2 inhibitors)
History of stomach or gastrointestinal conditions (inflammatory bowel disease, Crohn's disease, malabsorption, etc.)
Colostomy, bowel resection, bariatric surgery or other major gastrointestinal surgery
Chalmers University of Technology
Lead sponsor
Federico II University of Naples, Department of Clinical Medicine and Surgery, Naples, Italy
Collaborator
Göteborg University
Collaborator