This study evaluates a novel treatment approach for medication overuse headache (MOH) using greater occipital nerve pulsed radiofrequency (GONPRF).
Three treatment strategies are compared:
Standard Treatment: Limitation of overused acute headache medications, lifestyle counseling, and continuation of existing preventive medications.
Primary GONPRF: GONPRF administered in addition to standard treatment.
Modified GONPRF: GONPRF administered as a second-line intervention in individuals who do not respond adequately to standard treatment alone.
The study assesses whether GONPRF, when applied early or after an initial period of standard care, reduces monthly headache days more rapidly and effectively than standard treatment alone. Outcomes are evaluated over a 6-month follow-up period using headache diaries and scheduled clinical assessments.
This is a randomized controlled trial designed to systematically evaluate the clinical benefit of GONPRF in patients with medication overuse headache.
Age 18-65 years
Diagnosed with Medication Overuse Headache (MOH) according to ICHD-3 criteria
No laboratory evidence of bleeding or clotting disorders
No active infection
Changes in preventive treatment for migraine and/or tension-type headache within the last 3 months
Severe systemic disease (e.g., uncontrolled diabetes, serious cardiovascular disease, malignancy)
Psychiatric disorders (including current antidepressant use or psychiatric follow-up)
History of alcohol or substance abuse