This is a monocentric prospective observational study. This study will include patients with a diagnosis of non-small cell lung cancer for the collection of blood and tissue specimens.
Participant is willing and able to provide informed consent for participation in the study.
Age: Adults aged 18 years or older.
Diagnosis: non-small cell lung cancer (Stage I-II, III), with or without lymph node involvement, ideally with sufficient tumor burden to provide adequate tissue for analysis. In accordance with good clinical practice, patients with early-stage disease will undergo direct surgery, whereas patients with advanced-stage disease will receive neoadjuvant treatment followed by surgery.
Ability to attend scheduled follow-up visits, if applicable, for additional peripheral blood sample collection during treatment.
Presence of any active infection or underlying condition that could compromise the safety of tissue and blood sampling.
Prior history of another malignancy that might interfere with data interpretation related to non-small cell lung cancer progression and immune response.
Any current use of immunosuppressive medications (e.g., high-dose steroids) which might alter immune response assessments, except as part of non-small cell lung cancer treatment.
Pregnancy and breastfeeding
Ospedale San Raffaele
Lead sponsor
Fondazione Umberto Veronesi
Collaborator