* Herpesvirus infections may be severe in immunocompromised patients, with a high risk of complications and mortality. * Recipients of hematopoietic stem cell transplant (HSCT) or patients receiving high-intensity chemotherapy for hematological malignancies are the most vulnerable individuals. * Although the worldwide prevalence of herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV), antiviral prophylaxis in seropositive HSCT recipients has significantly reduced the rate of infection. * Acyclovir (ACV) is the first-choice drug for the prophylaxis or the therapy of that kind of infection. * Since the beginning, ACV has demonstrated to be characterized by a large interpatient variability, especially in children. * Therefore, therapeutic drug monitoring and pharmacokinetic studies may help in optimizing drug in children with malignancies.
Patients with Hematological malignancies
HSCT recipients who require ACV prophylaxis or treatment for HSV-VZV infection or
Children undergoing high-intensity antineoplastic chemotherapy who need ACV treatment.
Intravenous or oral ACV dosing
lack of signed informed consent
lack of TDM for ACV
unavailable patient's demographic characteristics
University of Pisa
Lead sponsor
IRCCS Burlo Garofolo
Collaborator